李小妹
一、個(gè)人簡(jiǎn)介
李小妹，1988年出生，基礎(chǔ)醫(yī)學(xué)院，副教授，碩士生導(dǎo)師；入選莆田市高層次人才第四類人才；主持國家自然科學(xué)基金青年科學(xué)基金項(xiàng)目1項(xiàng)，福建省自然基金青年創(chuàng)新項(xiàng)目1項(xiàng)，莆田市科技計(jì)劃項(xiàng)目1項(xiàng)；主要研究成果刊登于《Cell Death & Differentiation》、《Molecular Carcinogenesis》等國內(nèi)外學(xué)術(shù)期刊，其中SCI收錄8篇，中文CSCD核心1篇；獲莆田學(xué)院2022年度“科研先進(jìn)個(gè)人”稱號(hào)。主要研究方向：從事泛素介導(dǎo)的蛋白質(zhì)降解在疾病進(jìn)展等方面研究。
教育經(jīng)歷:
2017.09-2021.06廈門大學(xué)，博士，生理學(xué)
2011.09-2014.06福建師范大學(xué)，碩士，生物化學(xué)與分子生物學(xué)
工作經(jīng)歷:
2023.01-至今莆田學(xué)院，基礎(chǔ)醫(yī)學(xué)院，副教授
2021.08-2022.12莆田學(xué)院，基礎(chǔ)醫(yī)學(xué)院，講師
2015.07-2017.09莆田學(xué)院附屬醫(yī)院，中心實(shí)驗(yàn)室，科研人員
2014.07-2015.04中國科學(xué)研究院廣州能源研究所，能源化工實(shí)驗(yàn)室，研究助理
聯(lián)系方式：18450050730，郵箱：xmlee0104@163.com
二、科研項(xiàng)目
研究項(xiàng)目
1.“去泛素化酶USP39通過調(diào)控Wnt/β-catenin信號(hào)通路促進(jìn)肝臟再生的機(jī)制研究”，國家自然科學(xué)基金青年科學(xué)基金項(xiàng)目，2023-2025，主持，30萬；
2. “去泛素化酶USP39通過EZH2調(diào)控脂肪沉積在非酒精性脂肪肝中的作用及機(jī)制研究”，福建省自然基金青年創(chuàng)新項(xiàng)目，2022-2025，主持，8萬；
3. “USP39通過去泛素化調(diào)控β-catenin/c-Myc表達(dá)進(jìn)而促進(jìn)肝癌進(jìn)展的機(jī)制研究”，2021年度莆田學(xué)院引進(jìn)人才科研啟動(dòng)費(fèi)項(xiàng)目，2021-2024，主持，10萬；
4. “USP39 通過去泛素化 EZH2 調(diào)控 CCNB1 促進(jìn)肝癌進(jìn)展的機(jī)制研究”，莆田市科技計(jì)劃項(xiàng)目，2023-2026，主持，7萬；
三、科研成果
論文著作
1. Rong Zeng#, Xiaomei Li#, Fangfei Wang, Jinliang Xie, Conghua Song, Yong Xie.Reinforced medication adherence improves Helicobacter pylori eradication rate in developing countries: A systematic review and meta-analysis of randomized controlled trials. [J]. Helicobacter. 2023;28:e12989.
2. Xiaomei Li#, Jiahui Yuan#, Conghua Song, Yongbin Lei, Jiajia Xu, Gongye Zhang, Weiwei Wang, Gang Song*. Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma. [J]. Cell Death and Differentiation, 2021 Aug;28(8):2315-2332.
3. Jiahui Yuan#, Xiaomei Li#, Gongye Zhang, Weipeng Cheng, Weiwei Wang, Yongbin Lei, Qiujuan Ma, Gang Song*. USP39 mediates p21-dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis. Molecular Carcinogenesis. 2021 Apr; 60(4):265-278.
4. Xiaomei Li#, Rongxian Qiu#, Conghua Song#, Qinghua Huang, Xiaodong Wang, Zhenting Hu, Xiongzhi He, Xiangyang Ye, Xiaogang Huang, Fengfeng Zheng, Guoxian Lin*.Genotype and genetic variation of HCV infections with low-risk factors in Putian coastal regions, China. Epidemiology and Infection, 2017, Dec;145(16): 3385-3397.
5. Jiahui Yuan, Gongye Zhang, Xiaomei Li,Qiujuan Ma, Weipeng Cheng, Weiwei Wang, Bing Zhang, Tianhui Hu, Gang Song*. Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway [J]. International Journal of Molecular Sciences, 2020, Nov 25; 21(23): 8949.
6. Xiaomei Li#, Conghua Song#, Lian Xiong, Xuefang Chen, Chao Huang, Xiaoqing Lin, Xinde Chen*, Microbial Conversion of Wastewater from Butanol Fermentation to Microbial Oil and Biomass by Oleaginous Yeasts. Environmental Progress & Sustainable Energy, 2018, 37(3): 1220-1226.
7. Lin Chen#, Xiaomei Li#, Mingzi Wang, Jian Huang, Bilian Chen*, Xinglong Li, Xing Zheng, Utilization of gaseous emissions from a methanol plant for cultivation of Acutodesmus obliquus. Journal of Applied Phycology, 2016, 28: 2661–2669.
8. Xiaomei Li, Lian Xiong, Xuefang Chen, Chao Huang, Xinde Chen*, Longlong Ma, Effects of Acetic Acid on Growth and Lipid Productionby Cryptococcus albidus. Journal of the American Oil Chemists' Society, 2015, 92: 1113–1118；
9. Xiaomei Li, Mingzi Wang, Xinhui Liao, Han Chen, Youfen Dai, Bilian Chen*, Two Stages of N?Deficient Cultivation Enhance the Lipid Contentof Microalga Scenedesmus sp. Journal of the American Oil Chemists' Society, 2015, 92: 503–512；
10. 李小妹,廖興輝, 王明茲, 陳必鏈*. 兩步培養(yǎng)法提高柵藻的生物量及油脂含量[J]. 中國油脂, 2014, 39(5), 53-56.
